ABSTRACT
New developments in radiomics and bio-omics, blockchain, digital twins, cloud-to-edge computing, big data, and artificial intelligence are revolutionizing cancer radiotherapy, with breakthroughs in treatment accuracy and efficacy. Smart omics-guided radio-therapy will eventually resolve the problem of radiotherapy. In the radiotherapy decision-making, the whole genetic information and biological characteristics of tumors and individuals can be obtained through the methods of omics technology. For the determination of radiotherapy targets, through the image technique it provides the full genetics and microenvironmental information of the cancer lesion. For treatment response evaluation and follow-up, it can timely optimize the radiotherapy plan and monitor the tumor by real-time dynamic observation of changes in various histological information throughout the treatment process. The advantages of the treatment model are reflected in accurate decision-making, avoiding "blind people's touch" and partial errors. Holographic target iden-tification avoids the uncertainty caused by manual delineation of targets, and full and dynamic histological evaluation can promote the early detection of tumor recurrence.